Role of Osteoprotegerin (OPG) in Bone Marrow Adipogenesis

Role of Osteoprotegerin (OPG) in Bone Marrow Adipogenesis.

BACKGROUND/AIMS Bone marrow adipogenesis is one of the major characteristics of aged bone. Bone marrow mesenchymal stem cells (BMMSCs) prefer to differentiate into adipocytes instead of osteoblasts in the bone marrow cavity in aged hosts. The mechanism of formation and function of adipocytes in aged bone marrow needs further investigation. Osteoprotegerin (OPG) is a member of the tumor necrosis...

Role of osteoprotegerin (OPG) in cancer.

OPG (osteoprotegerin), a secreted member of the TNF (tumour necrosis factor) receptor superfamily, has a variety of biological functions which include the regulation of bone turnover. OPG is a potent inhibitor of osteoclastic bone resorption and has been investigated as a potential therapeutic for the treatment of both osteoporosis and tumour-induced bone disease. Indeed, in murine models of ca...

The Role of Bone Marrow Aspiration and Bone Marrow Biopsy in Diagnosis of Bone Marrow Metastases

Background: Bone marrow is the site of many malignant disorders and it is one of the common places for solid tumors to metastasize. Examination of the bone marrow aspirate and biopsy is a routine procedure performed for assessment of various conditions such as cytopenias, hematologic neoplasms, nonmalignant disorders and metastatic neoplasms. Methods: The patients were referred to the Hema...

Bone Marrow Adipogenesis in Osteoporosis

Bone marrow adipogenesis is a postnatal event during bone and marrow development. In the adult bone, marrow adipocytes occupy the largest space of the marrow cavity, and serve as a source of energy, autocrine and paracrine factors. Marrow adipocyte share a common multipotential mesenchymal stem cell with other marrow stomal lineages, and functional overlap exists among them. In the marrow strom...

The osteoprotegerin/osteoprotegerin ligand family: role in inflammation and bone